British researchers, in a study published in a British Medical Journal in , have also found out that chronic users of paracetamol - those who typically take large, daily doses over several years - may increase their risk of death, or develop complications in the kidneys, intestines, and the heart.
In , a similar study by Professor Michael Doherty observed almost patients aged 40 and older who took paracetamol, ibuprofen or a combination of both for chronic knee pain. After 13 weeks, one in five on paracetamol suffered from internal bleeding. Long-term use of paracetamol may also cause heart problems. The systematic review of eight observational studies showed that four found a heightened risk, ranging from 19 to 68 percent , of cardiovascular problems.
Higher doses of paracetamol was also associated with heart attack and stroke , according to another study. The systematic review also linked long-term use of paracetamol with an increased risk of impaired kidney function.
Four studies revealed kidney effects while three found that increased dose result to poorer kidney function. The analysis of all eight cohort studies said that in all cases, the risk was dose-dependent - the higher the dose, the greater the risk. Avoid Self Medicating When used correctly and within the right dosage, paracetamol is a safe, non-prescription pain reliever.
But it should be viewed as a serious drug and not like a piece of candy that you can pop daily. The best way to avoid any health risk is to get a proper diagnosis and treatment plan. Load More. Paracetamol can be safely used by adults, including if you are pregnant, but there is a limit to the amount of paracetamol that you can safely take in a hour period. Taking more than the daily limit is very harmful to your liver.
For adults, the usual maximum dose is 4 grams per day. This may be less if you are frail or elderly.
Check the ingredients of cold and flu medicines before you take them. If you do take other medicines that have paracetamol in them, be careful not to take more than the recommended dose of paracetamol each day 4 grams in 24 hours. Check with your pharmacist if you are not sure whether a product contains paracetamol. Paracetamol is a very popular medicine and when taken correctly works well.
However, too much paracetamol is very harmful to your liver. If you or someone you know have taken more than the recommended dose of paracetamol , even if there are no symptoms, seek advice immediately. Asking about your treatment or medication is important to help you understand your options. Read our guide of important questions to ask your pharmacist or doctor before taking a medicine.
You can also visit healthdirect's list of medicines that contain paracetamol to read the Consumer Medicines Information for the brand of paracetamol prescribed. Learn more here about the development and quality assurance of healthdirect content. The correct dose of paracetamol for a child depends on their weight. Find out about using paracetamol in kids. Read more on myDr website.
Read more on Alcohol and Drug Foundation website. Paracetamol is commonly used, but misuse and overdoses do occur. Patient education on the safe use of paracetamol is crucial in preventing accidental overdose. Paracetamol is one of the most commonly used over-the-counter analgesics in Australia and overdose rates continue to rise. Public misunderstanding about the safety of paracetamol and easy access to large quantities of paracetamol may be contributing to this rise.
Find out more. The combination of paracetamol and ibuprofen has been assessed in a variety of acute pain states but has been best studied in people after dental surgery.
An Australian study found that paracetamol is not effective for acute low back pain. What is the best way to manage acute low back pain? Paracetamol can be a safe medicine for pain relief and fever reduction when: used in accordance with the directions on the label care is tak.
Authors' conclusions: Since the last version of this review, we have found 39 new studies providing additional information. Read more on Cochrane Australasian Centre website.
Read more on Australian Prescriber website. It is important for patients being discharged from hospital after surgery to have a pain-management plan. Patients with low back pain may expect imaging and medicines that can be unnecessary and even harmful. Read more on ways to manage this difficult situation. Management of osteoarthritis should be based on a combination of non-drug and drug treatments targeted towards prevention, modifying risk and disease Patients sometimes present to a medical practitioner with dental pain if they cannot see a dentist.
There is little evidence to guide therapy because of the difficulties in studying specific interventions in complex regional pain syndrome.
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